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Your Position: Start > IL-31 RA

IL-31 RA

Brief Information

Name:Interleukin-31 receptor subunit alpha
Target Synonym:GLM-R,CRL,IL-31R subunit alpha,IL-31 receptor subunit alpha,Cytokine receptor-like 3,Gp130-like monocyte receptor,IL-31RA,ZcytoR17,IL-31R-alpha,PRO21384,GPL,CRL3,GLMR,Interleukin 31 Receptor A,Soluble Type I Cytokine Receptor CRL3,PLCA2,Class I Cytokine Receptor,hGLM-R,Gp130-like receptor
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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ILA-H82F6 Human Biotinylated Human IL-31 RA Protein, Fc,Avitag™
ILA-H82F6-sds
ILA-M5254 Mouse Mouse IL-31 RA Protein, Fc Tag
ILA-M5254-structure
ILA-M5254-sds
ILA-H525b Cynomolgus / Rhesus macaque Cynomolgus/Rhesus macaque IL-31 RA Protein, Fc Tag
ILA-H525b-structure
ILA-H525b-sds
ILA-H82E9 Human Biotinylated Human IL-31 RA Protein, His,Avitag™
ILA-H82E9-structure
ILA-H82E9-sds
ILA-H52H7 Human Human IL-31 RA Protein, His Tag (MALS & SPR verified)
ILA-H52H7-structure
ILA-H52H7-sds
ILA-H5256 Human Human IL-31 RA Protein, Fc Tag
ILA-H5256-structure
ILA-H5256-sds
ACRO Quality

Part of Bioactivity data

ILA-H52H7-SPR
IL-31 RA SPR

Human IL-31, His Tag (Cat. No. IL1-H5247) immobilized on CM5 Chip can bind Human IL-31 RA, His Tag (Cat. No. ILA-H52H7) with an affinity constant of 52.1 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
ILA-H5256-SPR
IL-31 RA SPR

Human IL-31, His Tag (Cat. No. IL1-H5247) capture on NTA-Series S sensor chip can bind Human IL-31 RA, Fc Tag (Cat. No. ILA-H5256) with an affinity constant of 37.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

IL-31 RA,IL-31RA,hGLM-R,CRL3,GPL,ZcytoR17,GLM-R,IL-31R-alpha,Gp130-like receptor

Background

Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Nemolizumab CD-14152; CIM-331 Approved Chugai Pharmaceutical Co Ltd Mitchga Japan Dermatitis, Atopic; Pruritus Maruho Co Ltd 2022-03-28 Pruritus; Scleroderma, Systemic; Prurigo; Renal Insufficiency, Chronic; Dermatitis, Atopic Details
Nemolizumab CD-14152; CIM-331 Approved Chugai Pharmaceutical Co Ltd Mitchga Japan Dermatitis, Atopic; Pruritus Maruho Co Ltd 2022-03-28 Pruritus; Scleroderma, Systemic; Prurigo; Renal Insufficiency, Chronic; Dermatitis, Atopic Details

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